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10.1016/S0076-6879(05)01027-X Methods Enzymol

Int Immunopharmacol 96:107779 Gautam R, Singh M, Gautam S, Rawat JK, Saraf SA, Kaithwas G (2016) Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects

I am flawed

If this trash builds up, it causes Oxidative Stress, which breaks down cell walls and damages DNA

The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)

A main emerging concept is that these two neural cell types have different and energetically adapted glyoxalase defense mechanisms which may serve as protective mechanism against methylglyoxal-induced cellular damage