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[] The clinical relevance of PPARs in human cardiometabolic diseases is well established

Azad 2014)

However, in some other tissues, IGF-I expression appears to be regulated by tissue specific trophic factors, as for example in uterus, where estrogens (and not GH) stimulate IGF-I expression[26], while follicle stimulating hormone is a major IGF-I regulator in ovary[27]