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& Chen, K.-Y

However, secondary drug resistance is an obstacle for achieving a satisfactory therapeutic effect, mainly due to the presence of EGFR T790M mutation, which represents a marker of secondary drug resistance and the amplification of MET gene expression (81)

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Activated B cells can migrate to bone tissue and directly promote osteoclast formation by releasing osteoclastogenic factors: RANKL, TNF, and IL-1, thereby accelerating bone resorption (234)