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The Phase 2 trial demonstrated that gradual dose titration reduced the incidence of GI adverse events compared to starting at the target dose directly

There were no significant differences in the transcriptional expression for other Enzyme Nomenclature (EC) of KEGG enzyme (Fig

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Uric acid increased protein carbonylation levels in a dose-dependent manner

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hence, it plays a crucial function in the central nervous system (Glick et al., 2010