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Food Chem 113(4):859871

Best Pract

[] found that oral administration of madecassoside significantly relieved the symptoms of collagen-induced arthritis in rats, but its primary metabolite, madecassoside, did not have this effect

And these are beautiful studies done in humans, of course

That hypothesis has also been supported by other studies, which demonstrates the regulation of HIF activity by mitochondrial-derived ROS under hypoxia, growth factors [73,74,75], and antioxidants [76,77,78]