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Furthermore, rising oxidative stress indicators and reduced antioxidant enzymes point to a disrupted redox state, resulting in mitochondrial dysfunction, neuronal death, and inflammation, hallmarks of neurodegeneration

Cho JH, et al

Oral formats of SLU-PP-332 therefore have no published evidence of producing the systemic ERR agonism observed in the IP-route mouse studies

PMID: 176 XingCYangFLinYShanJYiXAliFet al

Therefore, given the central role of NRF2 in regulating antioxidant defense mechanisms, subsequent oocyte experiments were conducted using only these two antioxidants, QUE and SFN