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Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment

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Overall, this work proposed a convenient, safe, and effective rectal drug delivery strategy, providing a new candidate for the prevention and treatment of radiation-induced proctitis, and also providing a reference for the design of multifunctional local delivery systems in radiation-associated tissue injury

They may have even received a diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS)