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Bone as a target organ in rheumatic disease: impact on osteoclasts and osteoblasts

1 Introduction In 2024, the International Agency for Research on Cancer (IARC) released the latest GLOBOCAN 2022 database, which encompasses data on the incidence and mortality of 36 types of cancer across 185 countries or regions worldwide

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[3] [5] Topical application also keeps the copper load overwhelmingly local: intact stratum corneum is a substantial barrier to a ~403 Da charged metal complex, which limits systemic copper exposure the same barrier property that limits topical efficacy is what limits topical copper risk

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Based on the summary-level genome-wide association studies (GWAS) data from a publicly available database, the variance weighted inverse (IVW) was applied as the primary method to estimate causality, and other estimators were used as complementary methods