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As a result, a selfperpetuating cycle wherein mitochondrial dysfunction enhances ROS production, and elevated ROS further compromises mitochondrial integrity [58]

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Discussion Numerous studies have documented that HFD in rats induces insulin resistance, while low-dose STZ administration selectively impairs insulin secretion, replicating the progressive nature of T2DM

Utilizing Catalase in Combination Therapies for Enhanced Antioxidant Capacity A synergistic approach involving catalase in combination with other antioxidants has shown promise in enhancing antioxidant capacity and mitigating oxidative stress-induced damage

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