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BMC Neurosci 2001

The availability of real-world data from insurance claims, combined with whole transcriptome sequencing, offers a unique opportunity to evaluate resistance mechanisms across key pathways in an unbiased and comprehensive manner

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The hypothesis is that targeting both pathways simultaneously produces additive weight loss beyond what either agent can achieve alone

Early impairment of NGF/TrkA signaling in AD can lead to reduced synaptic vesicle secretion and decreased presynaptic protein expression, resulting in presynaptic functional impairment of cholinergic primary neurons [88]