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Moreover, daily administration led to a 55% increase in IGF-1 levels at two weeks and 88% at four weeks [16]

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As for the latter, for example, it has been observed that the supernatant of Lactobacillus delbrueckii CU/22 could lead to the apoptosis and necrosis of HT-29 cells, suggesting that careful consideration ought to be involved in choosing probiotics as adjuvant therapy of IBD [9]

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