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The transcription level of IL-4 significantly increased in wild type group at later timepoints ( Figure 6E )

doi: 10.1016/j.neubiorev.2016.09.001 111

The attention for this compound was drawn by the findings of Carlton that cuprizone possesses various biotoxic effects in rodents like growth retardation, pregnancy disturbances, and severe CNS pathology, including demyelination, astrogliosis, and hydrocephalus (Carlton, 1966, 1967, 1969)

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In a double-blind study in patients with peripheral venous insufficiency, symptoms were significantly reduced in 75% of participants who received 300 mg of grape seed proanthocyanidins daily