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Interestingly, a similar protective effect of TF was observed in differentiated ARPE-19 cells exposed to FeCl, further supporting the relevance of these findings (Supplementary Fig

This can be achieved through various methods such as sonication, freeze-thaw cycles, enzymatic digestion (e.g., lysozyme treatment), or mechanical disruption (e.g., French press)

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Through phosphorylation of the downstream SREBP1-SCD1, mTOR1 facilitates the synthesis of GPX4 and GSH, thereby enhancing the resistance of tumor cells to ferroptosis (Yi et al., 2020)

pylori , which are involved in the transport of these factors, can also influence apoptosis through their various biologically active compounds ( H