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Chinese Academy of Medical Sciences and Peking Union Medical College

While I usually recommend the methylated version of B12 (such as the one by Pure Encapsulations), individuals with the COMT genetic SNP may benefit more from the hydroxy- or adeno- forms of B12

Proline introduces rigid kinks into peptide backbones, and proline-rich peptides typically show greater resistance to enzymatic degradation than linear peptides of comparable length

It also significantly improved systolic blood pressure, waist circumference, lipid levels, and glycemic control

As we get older, the body becomes less efficient at absorbing B12 from food

An enzyme called NNMT (nicotinamide N-methyltransferase) drains the NAD+ salvage pathway by methylating nicotinamide, one of NAD+'s precursors