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Statistical analysis Assuming a proportion of participants experiencing overcorrection based on previous literature 13,16,21 , we determined that a sample size of 66 participants would yield 80% statistical power to detect a significant difference in the incidence of overcorrection between the proactive and reactive groups, employing an alpha () level of 0.05, beta () of 0.2, and accounting for a 10% dropout rate

Chiang HL, Terlecky SR, Plant CP, Dice JF (1989) A role for a 70-kilodaton heat shock protein in lysosomal degradation of intracellular proteins

The primary mode of NRF2 regulation is at the protein level, with three primary E3 ubiquitin ligase complexes mediating the ubiquitylation and subsequent degradation of NRF2 by the 26S proteasome: 1 ) KEAP1-CUL3-RBX1, 2 ) HRD1 (also known as synoviolin), and 3 ) SCF/-TRCP

however, microglial activation was only reduced in male rats

leukotriene B 4 ) in promoting uncontrolled inflammation and formation of vulnerable plaques (209)