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The development NAFLD is driven by a complex interplay of factors, including dyslipidemia, impaired insulin signaling, and dysregulated adipocyte activity, along with the release of inflammatory mediators from both immune cells and adipose tissue

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In principle, it is a more instrumentally sophisticated version of the long-employed test for urinary thiols excretion based on alkaline decomposition of urinary glutathione and mercapturic conjugates and on the measurement of the released thiols as a whole with the Ellmann reaction