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Children receiving CRWP showed a significant increase in glutathione levels and selective improvements in adaptive behavior and socialization domains (Castejon et al., 2021)

These studies have also brought to light their potential as a rich and unexplored source for new therapeutic targets and agents through multiple avenues, including direct targeting of the catalytic sites, controlling disease-associated proteinprotein interactions and developing novel biologics from the secreted ARS proteins or their parts

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If continued worsening occurs, combination therapy of LABA plus LAMA is recommended

The gut microbiota also influences DA levels in the frontal cortex and striatum of rodents, and perturbations of the dopaminergic system are associated with mood-related disorders and cognitive dysfunction

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