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7-glutathione Pyrrole Adduct: a Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids

Rzsa et al

In these experiments, we demonstrated that the exacerbation of ferroptosis leads to the occurrence of EBV reactivation and that the inhibition of ferroptosis can inhibit EBV reactivation to a certain extent

5), and that the expanded polyQ proteins associate with, and linger within, IFD inclusions in proteostressed neurons (Fig

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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling