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It is difficult to give a one-size-fits-all answer to the question, "How long does it take for B12 injections to work." It is possible for some individuals to notice the improvement in their symptoms right away, whereas, for others, it may take additional injections to achieve optimal health

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For example, high plasma concentrations of vitamin B12 have been associated with increased risks of certain types of cancer [31, 32] and all-cause mortality [33]

Improper storage degrades the peptide, reducing its effective concentration even though the label has not changed

How do I know if I need a B12 supplement

Critical Reviews in Biochemistry and Molecular Biology