AP-1 activator protein 1 ATP adenosine triphosphate BALT bronchial-associated lymphoid tissue BCR B-cell receptor Ca 2+ calcium CCL-2 CC motif chemokine ligand 2 CCR9 CC motif chemokine receptor 9 CD cluster of differentiation COPD chronic obstructive pulmonary disease COVID-19 coronavirus disease 2019 CRP C-reactive protein DAMPs damage-associated molecular patterns DCs dendritic cells DNA deoxyribonucleic acid EC epicatechin ECG epicatechin-3-gallate EGC epigallocatechin EGCG epigallocatechin-3-gallate FcR Fc alpha receptor FOXP3 forkhead box transcription factor P3 GATA3 GATA-binding protein 3 GSH-Px glutathione peroxidase HATs histone acetyltransferases HCMV human cytomegalovirus HDAC histone deacetylase hTBE tracheobronchial epithelium IFN interferon IFNAR interferon alpha and beta receptor Ig immunoglobulin IKK IB kinase IL interleukin ILCs innate lymphoid cells ISGs interferon-stimulated genes IB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor JAK/STAT janus kinase / signal transducer and activator of transcription MAMPs microbial-associated molecular patterns MgSO 4 magnesium sulfate miRNAs microRNA NEBs neuroepithelial bodies NF-B nuclear factor kappa-light-chain-enhancer of activated B cells NK natural killer cells NLR nucleotide-binding oligomerization domain OR Nod-like receptor Nrf2 nuclear-related factor 2 PAMPs pathogen-associated molecular patterns PBMC peripheral blood mononuclear cell PGC peroxisome proliferator-activated receptor-gamma coactivator PGE 2 prostaglandin E 2 PNECs pulmonary neuroendocrine cells PRRs pattern recognition receptors RA retinoic acid RDS respiratory distress syndrome RIG-1 retinoic acid-inducible gene I RNA ribonucleic acid RORt retinoic acid-related orphan receptor gamma t ROS oxygen species RSV respiratory syncytial virus SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 SCFAs short-chain fatty acids SFB segmented filamentous bacteria SIRP signal regulatory protein SIRT1 sirtuin 1 TGF- transforming growth factor Th T helper TLRs Toll-like receptors TNFR tumor necrosis factor receptor Tregs regulatory T cells TREM2 triggering receptor expressed on myeloid cells 2 WHO World Health Organization ZIP10 zinc transporter 10 omega
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In addition to genetic factors affecting the pharmacokinetics of chemotherapeutic agents, several polymorphisms relating to pharmacodynamic effects have been causally implicated in the development of CIPN
Vitamin D supports blood vessel function and inflammation control, while vitamin B12 helps regulate homocysteine levels, which are linked to heart disease risk
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