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Greenwald P'20 Andrew J

Use of ultrasound monitoring of ovarian response and/or measurement of serum estradiol levels is important to minimize the risk of ovarian stimulation [see Warnings and Precautions (5.12)]

Daily use is common in research protocols, typically for 4-8 week cycles

Melatonin in female fertility: Multifaceted role from reproductive physiology to therapeutic potential in polycystic ovary syndrome, endometriosis, and ovarian failure

Side Effects The most common side effects are gastrointestinal symptoms, injection-site reactions, mild flu-like symptoms, and transient headaches

But that forced sedation comes at a cost: altered sleep architecture, next-day grogginess, tolerance development, dependency risk, and rebound insomnia when you stop taking them