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Therapeutic targets for treating fibrotic kidney diseases

Struyfs, C., Cammue, B., and Thevissen, K., Front

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A more comprehensive understanding of these mechanisms may clarify the potential of GSH-degrading enzymes as targets for tumor diagnosis and therapeutic interventions

However, a significant limitation across many studies is the reliance on in vivo phenotypic readouts without robust in vitro mechanistic validation, making it difficult to distinguish direct immunomodulatory effects from secondary consequences

GPX4 knockdown keratinocytes appeared to have a decreased capacity for cell adhesion, along with accumulating lipid peroxides and enhanced levels of various pro-inflammatory elements, including COX-2, 4-HNE, and prostaglandins (Sengupta et al., 2013)