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Those experiencing unexplained high homocysteine levels

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doi:10.1016/j.amjoto.2014.06.009

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Inactivating mutations in TSC1/TSC2 or PML which negatively regulates mTORC1 association with RHEB and activating mutations in mTOR increase HIF-1 expression to influence the hypoxia-induced transcriptional landscape 221,225227