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For more detailed information regarding the DTTC hierarchy please see the references below ( American Journal of Speech-Language Pathology, Strand, Edyth, Vol

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Phase I activity converts toxin molecules into reactive intermediate substances (activated toxins), producing free radicals in the process

In melanoma, ROS is also capable of ectopic peroxisome proliferator activated receptor- from the nucleus into the cytoplasm via mitogen-activated protein kinase kinase 1, thereby inducing an increase in TNF-, which not only plays an antitumor role, but also converts TAMs into a phenotype that promotes tumor invasion (112)

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