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Dose-related adverse effects of Zoloft have been reported, such as the emergence of hypomania at 300 mg/day, which was reversed once the dosage was lowered to 200 mg/day

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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome