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Even moderate alcohol consumption can decrease vitamin B12 absorption by about 5-6% Symptoms of Vitamin B12 Deficiency Historical records suggest that Grigori Rasputin suffered from a vitamin B12 deficiency

Conservative dosing initially (in research context) and close follow-up for signs of malignant transformation

If you are taking metformin, colchicine, or proton pump inhibitors long-term, discuss B12 monitoring with your GP, as these medications can affect B12 status over time