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This review focuses on recent studies, demonstrating the actions of local IGF-I/IGF-IR signaling in (a) supporting skeletal development and remodeling, (b) cross-talk with other autocrine/paracrine pathways in the bone, (c) mediating cell-cell interactions between various types of skeletal cells, and (d) integration with systemic signals to produce skeletal anabolism

36 Lactate, the end product of glycolytic metabolism, serves as an energy substrate for neuronal activity in the brain and functions as an intercellular signaling molecule

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Without it, collagen synthesis is impaired even if youre taking plenty of collagen