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Legitimate access to the compounds with an approved or off-label clinical pathway, tesamorelin and sermorelin among them, generally runs through a licensed prescriber or telehealth hormone clinic dispensing through a state-licensed compounding pharmacy

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Some sources recommend refrigeration even before reconstitution for extended shelf life

To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed