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Posner BI, Laporte SA

Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial

Future outlook: data from preclinical studies Although the mechanisms underlying CIPN are relatively well understood, the available results of clinical trials clearly indicate that the success rate for the introduction of novel drugs that are able to prevent CIPN is low [50], the progress in this area is slow and, at present, there is insufficient evidence to recommend any specific agent for CIPN prevention

Guidelines are specified following disease state

Guo H, Xu Y, Wang F, Shen Z, Tuo X, Qian H, et al

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