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Antibiotic-induced gut dysbiosis did not lead to oxidative stress Another factor that can lead to cognitive decline is oxidative stress

Long-term and short-term Cdk5 knockdown also both inhibited insoluble tau aggregation in the hippocampus of 3xTg-AD mice and improved their spatial memory (Uchida et al., 2005)

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doi: 10.1016/j.eclinm.2024.102884

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In knockout mice deficient in hepatic S-adenosylmethionine synthesis, another model of MASH, a proteomic analysis showed upregulation in liver CAT expression as well as in the expression of SOD1 and GPx, a result which may reflect an adaptive mechanism to dissipate oxidative stress generated by oxidant genes (Santamaria et al