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Using measurement of radioactivity excreted in the urine, a test result indicating uptake of B12 was considered conclusive, whereas a test result suggesting no uptake should be judged with caution

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In B12 deficiency, DNA synthesis in red blood cell precursors (erythroblasts) can be impaired, preventing the normal maturation and division of these cells, resulting in larger-than-normal red blood cells

Zimmet, P., Alberti, K