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Low-Se diet can affect sperm quality and testicular glutathione peroxidase-4 activity in rats

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Interestingly, homocysteine levels have been positively associated with serum GGT, suggesting elevations in homocysteine may at least partly be due to increased shunting toward glutathione synthesis in response to increased GSH demands, though this has not been proven as of yet

These observations further suggests that the hypoxic microenvironment is closely associated with the development of cutaneous calciphylaxis in MS patients and is involved in their vascular pathology and calcium salt deposition