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B12 deficiency symptoms to watch for Even with the B12 in your compounded formulation, it is worth knowing what deficiency looks like

Review of Studies Examining How Metformin Affects the Status of Specific Micronutrients and the Microbiome Vitamin B1 Vitamin B1 (thiamine) acts as a coenzyme in neurotransmission and low levels of this nutrient may have a role in the development of certain diabetic complications

San Diego: : Academic Press 2015

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Competitive and syntrophic interactions for B12 exist between microbes in the gut

Additionally, the absorption process itself is competitive, with amino acids and other nutrients vying for uptake in the small intestine