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It is important to note that the positive health impact of the MeD derives from the synergy of bioactive compounds and nutrients that interact with each other, producing increasing beneficial effects, which cannot be replicated by pharmacologically supplementing a single component [15, 62, 175, 190]

Resin blocks were ultra thin sectioned on a Leica Ultracut UC6 ultramicrotome (Leica Inc., Nussloch, Germany)