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This hypothesis is supported by initial experimental evaluation of ADO in paired blood and BM plasma samples from MM patients, obtained before and after treatment with daratumumab (in collaboration with Dr

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In Pelizaeus-Merzbacher disease, a myelination defect, a subgroup of mutations affecting the extracellular loop of the PLP/DM20 protein impair formation of intramolecular disulfide bridges and cause abnormal protein cross-links, ER retention and oligodendrocyte death (Dhaunchak et al., 2005) and von Willebrand disease (Wang et al., 2012)

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