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SAMe functions in this capacity as well as participating in a large number of other critical cellular processes and biochemical pathways)

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It inhibits HSP90, which in turn inhibits GPX4 degradation and lipid peroxidation, and downregulates ROS, protecting cells from damage caused byferroptosis (Wu et al., 2019)

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275 As an alternative to radiolabels, tRNAs precharged with a noncanonical amino acid containing a trackable modification (e.g., a fluorophore or biotin) are also widely used to stochastically label the native protein sequences produced in CFE