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It can affect immune signaling, gut function, detoxification pathways, sleep quality, and endocrine resilience

10.1681/ASN.2006040415 54 HarrisM.BryantL

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Depending on the DA-R bound, CB1-R can contribute in different ways to the modulation of both excitatory and inhibitory synaptic functions as well as to the decrease of neurotransmitter release in the basal ganglia circuitry (for rev., see [40])