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Nuclear factor erythroid 2-related factor (Nrf2) is a transcription factor that is kept in the cytoplasm in an inactive form by its inhibitor Keap1

Two antibody-based approaches have been developed to mimic FGF21 signaling through FGFR1c only

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Studies have shown that in a mouse model of ischemic stroke, the level of GSH in neurons is significantly decreased, the degree of lipid peroxidation is enhanced, and the activity of GPX is decreased 71