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Description

We determined the effect of the compounds to promote oligodendrogenesis at the lesion site by combinatory immunodetection of Olig2, CC1, and Olig1, allowing to distinguish OPCs (Olig2 high /CC1 - /Olig1 nuclear-cyto cells) and three stages in OL differentiation 53,84 : immature OL (iOL) 1 (iOL1, Olig2 high /CC1 high /Olig1 - cells), iOL2 (Olig2 high /CC1 high /Olig1 high-cyto cells), and mOL (Olig2 low /CC1 low /Olig1 low cells