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Previous studies have found that activation of TRPV1 can significantly reduce cartilage degeneration by upregulating GPX4 and eliminating ferroptosis in chondrocytes

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Akt2-/- mice are more resistant to LPS-induced endotoxin shock and to dextran sulfate sodium-induced colitis than wild-type mice, whereas Akt1 ablation renders the mice more sensitive to LPSinduced endotoxin shock [50]