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Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 2 factorial, randomised, crossover study in human individuals

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While promoting growth is important, its not enough on its own

The formation of heterodimers, more commonly named hybrid receptors, between type A or B isoforms of the insulin receptors (INSR A or INSR B ) and the IGF1R of which IR A -IGF1R are highly expressed in the fetus (and in malignant cells) and activated by IGF-II, may further point to the importance of IGF-II during the fetal period

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