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10.1186/s13054-019-2328-6 36 ElakkadY

Talanta 226, 122131

Since E2F is a transcriptional activator of PDK2, its inhibition prevents Warburg metabolism, reduces lactate production, and promotes pyruvate flux into acetyl-CoA, thereby attenuating cisplatin resistance [135]

TRP14 inhibits osteoclast differentiation via its catalytic activity

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These include phagosome maturation, leukocyte extravasation signaling, tight junction signaling, ILK signaling, IL-8 signaling, clathrin-mediated endocytosis signaling, caveolin-mediated endocytosis signaling, glucocorticoid receptor signaling, NRF2-mediated oxidative stress response and RhoA signaling (Fig