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8.1 In vitro studies In vitro studies show that P

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Case 1 A 39-year-old female with characteristic symptoms and signs of the Flammer syndrome phenotype (FSF) (low BMI, low BP, frequently cold extremities, migraine with aura, sporadic arrhythmias, tinnitus, hard-to-heal wounds, shifted circadian rhythm, increased sensitivity towards stress and medication, meticulous personality, regular body exercise, etc.)

Cancer Chemother Pharmacol 78(5):881893

However, during clinical trials in the UK, an unexpected side effect emerged, causing penile erections for which Viagra was marketed in 1998 in the indication of impotence (Ghofrani et al., 2006