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Nature 415 , 141147 (2002)

Many factors, including radiation, chemicals, viruses, genetic and epigenetic changes, lead to abnormal proliferation of a single cell, which results in the outgrowth of a population of clonal-derived tumour cells

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We further observed that the JE2 thiE mutant with defective thiamine phosphate production was more sensitive than the wildtype JE2 strain to DSF but not DDTC