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* Correspondence: Jun Qian, [email protected] Wu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The definite toxicity, safety margin and potential adverse reactions have not been reported

Oxidation of the histidine residue progresses continuously even under ideal conditions

This range balances the need to reach receptor saturation thresholds with minimizing systemic exposure in early trials

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Thus, histidine is a relatively strong field ligand ,compared to water and other amino acid side chain ligands, and would encourage a relatively large