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doi: 10.1016/j.toxrep.2019.10.001 101 JabczykMNowakJHudzikBZubelewicz-SzkodziskaB

Neurotoxicology 40, 111122

This distinction has important implications for therapeutic timing: anti-inflammatory interventions may be most effective if initiated early post-insult to prevent the establishment of chronic tinnitus, but may also confer benefit in established tinnitus by reducing sustained inflammatory signaling that perpetuates maladaptive plasticity

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Birngruber T, Raml R, Gladdines W, Gatschelhofer C, Gander E, Ghosh A, et al

SystemX c is composed of the transport subunit SLC7A11 and regulatory subunit SLC3A2 structurally, which are coupled by a disulfide bond (Sato et al., 1999)