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By PASS prediction 4-NP shows hematotoxicity 12 in vivo studies, other toxicity such as nephrotoxicity, and acetylcholine inhibitor

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The advantages are real: testosterone levels are highly controllable, can be pushed into the upper physiological range reliably, and the pharmacokinetics of injectable esters are well-characterized after decades of clinical use

Not many mechanistic studies have been done looking at the reactions of the flavin, but the proposed mechanism is shown below

10.1042/bj20041434 Biochem