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Glucose enters the cellular milieu through glucose transporter 1 (Glut-1), followed by conversion to pyruvate, which is mediated by a series of enzymatic steps, including glucose phosphorylation to glucose-6-phosphate (G-6-P), followed by conversion to pyruvate, reducing NAD + to NADH and generating ATP molecules via oxidative phosphorylation (OXPHOS) through the mitochondrial electron transport chain (ETC)

Mouse models lacking Parkin or PINK1 develop motor deficits and dopaminergic neuron loss when subjected to mitochondrial stress, particularly in combination with the mutator mouse model, which accumulates mtDNA mutations due to POlG dysfunction [60]

Histological analysis Rat tissues were serially sectioned at 4 m thicknesses and then mounted on slides for further study