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Keywords: mitragynine, 7-hydroxymitragynine, Mitragyna speciosa , mitragynine pseudoindoxyl, plasma stability, metabolism Mitragynine is the most abundant and pharmacologically well-characterized alkaloid ( 66% of total alkaloidal content) 1,2 contained in the psychoactive substance kratom ( Mitragyna speciosa Korth.)

This is thought to compromise mitochondrial functional complementation, content mixing, and efficient transport to axonal terminals

S-adenosylmethionine (SAMe) SAMe is an endogenous molecule formed from the amino acid L-methionine and ATP by the enzyme SAMe synthetase and initiates three metabolic pathways (Figure 1): 1