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The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons

If you are not producing enough glutathione then you wont be able to sufficiently neutralize the free radicals that are being produced by your thyroid gland

This complex epigenetically regulates gene expression by decreasing histone 2 A ubiquitination (H2Aub) on chromatin in nucleosomes [66,67,68,69,70,71]